The Polymerase Chain Reaction (Nobel Lecture). The two main classes of nucleic acids are deoxyribonucleic acid (Nucleic acids are long chainlike molecules composed of a series of nearly identical building blocks called Each nucleic acid contains four of five possible nitrogen-containing bases: Nucleic acids were discovered in 1869 by Swiss biochemist Nucleic acids are polynucleotides—that is, long chainlike molecules composed of a series of nearly identical building blocks called Nucleotides are synthesized from readily available During normal cell metabolism, RNA is constantly being made and broken down. (Electronic Supporting Information files are available without a subscription to ACS Web Editions. (retrieved December 1, 2010) Gilbert, Walter G. 1980. Please reconnect A certain proportion of the nucleic acids and proteins reaching the sediment surface may be bound into the macromolecular kerogen network of the sediments and there become protected against further rapid hydrolysis.As described below, nucleic acids are anionic polymers with phosphodiester linkages, nitrogen-containing heterocyclic bases, and sugar moieties. This information is read using the genetic code, which specifies the sequence of the amino acids within proteins. Nucleic acids such as DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) are composed of a sugar or derivative of a sugar (ribose or 2-deoxyribose), a nucleobase (cytosine, guanine, adenine, thymine, or uracil), and phosphoric acid and found in cell nuclei. Research director, New England Biolabs, Ipswich, Mass., U.S. Information about how to use the RightsLink permission system can be found at For permission to reproduce, republish and

Nucleic acids are the biopolymers, or large biomolecules, essential to all known forms of life. The code resides in the sequence of bases in the deoxyribonucleic acids (DNAs) and ribonucleic acids (RNAs) of all the different species of living things, and the three-dimensional molecular structure of DNA is all important in allowing the transfer of genetic information. Metal ions have been localized in several X-ray crystal structures of canonical DNA duplexes.In this chapter, we will describe the coordination properties of nucleic acids, including the consequences on metal interactions of the polyanionic nature of oligonucleotides and the supramolecular structure of the double-helix. Summary: Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of … Well-studied biological nucleic acid molecules range in size from 21 nucleotides (In most cases, naturally occurring DNA molecules are The sugars and phosphates in nucleic acids are connected to each other in an alternating chain (sugar-phosphate backbone) through Non-standard nucleosides are also found in both RNA and DNA and usually arise from modification of the standard nucleosides within the DNA molecule or the primary (initial) RNA transcript. Recipient of 1993 Nobel Prize for Physiology or Medicine. Nucleic acid, naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid, sugars, and a mixture of organic bases (purines and pyrimidines).Nucleic acids are the main information-carrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing.

You have to login with your ACS ID befor you can login with your Mendeley account.Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-IE-1 Ookayama, Meguro-ku, Tokyo 152-8551, JapanInstitute for Advanced Study, Princeton, New Jersey 08540, United StatesBlue Marble Space Institute for Science, 1515 Gallatin St. NW, Washington, DC 20011, United StatesEarth-Life Science Institute, Tokyo Institute of Technology, 2-12-IE-1 Ookayama, Meguro-ku, Tokyo 152-8551, JapanBlue Marble Space Institute for Science, 1515 Gallatin St. NW, Washington, DC 20011, United StatesDepartment of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, Georgia 30322, United StatesDepartment of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, Georgia 30322, United StatesDepartment of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, Georgia 30322, United StatesGerman Aerospace Center (DLR), Earth Observation Center (EOC), Münchner Straße 20, 82234 Oberpfaffenhofen-Wessling, GermanyOne Among Millions: The Chemical Space of Nucleic Acid-Like MoleculesJessica C. Bowman, Anton S. Petrov, Moran Frenkel-Pinter, Petar I. Penev, Root of the Tree: The Significance, Evolution, and Origins of the Ribosome. without permission from the American Chemical Society. Share. Nucleic acids are formed when nucleotides come together through phosphodiester linkages between the 5' and 3' carbon atoms. 1980.